Zopiclone (Fig.1) – branded as Zimovane – is a hyposedative, non-benzodiaepine cyclo-pyrrolone , which is also an agonist at the type A -aminobutyric acid (GABAA) , meaning that zopiclone is known to produce activity at the GABAA receptor complex (Fig.1) [3; 4]. In addition, the duration of zopiclone’s effects and action is determined by its pharmacokinetic profile, which suggests a delayed elimination time when compared to the hypnotic agent Zaleplon . Importantly, zopiclone is a commonly prescribed hypnotic drug which is usually employed – short-term – to treat sleeping difficulties . Zopiclone is considered a ‘Z-drug’, having notable high-affinity binding to the GABA receptor . Comparatively, zolpidem and zaleplon bind to the -1 subunit of the GABA receptors .
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