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Summary

Summary

Lunesta, also known as eszopiclone, was approved by the FDA in December, 2004, for the short-term treatment of insomnia [1].

Moreover, Lunesta is indicated for use in patients suffering from insomnia, above the age of 18 [1].

Figure 1. Lunesta, also known as eszopiclone, is a non-benzodiazepine hypnotic agent, with a molecular weight of 388.81.

 

lunesta chemical structure

Detailed

Mechanism

The mechanism of action of Lunesta can be related to its effects on the GABA receptors [2].

Lunesta lasts around 6-8 hours in the body [1].

Lunesta is metabolised mainly in the liver by two mechanisms: oxidation and de-methylation [1].

Pharmacokinetics

Once taken, Lunesta (eszopiclone) is rapidly absorbed from the gastrointestinal (GI) tract within one hour [3].

Peak plasma concentrations of Lunesta are reached after around 1 hour of oral administration, and is binds weakly to plasma protein [4].

Lunesta & Anxiety

Lunesta (eszopiclone) has been previously investigated to determine its effects on treating insomnia comorbid with generalised anxiety disorder (GAD) [7].

Patients, aged 18-64, who fulfilled the criteria for anxiety, were administered eszopiclone and escitalopram (which is also an anti-anxiety drug).

Results of this work showed an improvement in total Hamilton Anxiety Scale scores, over 10 weeks [7].

Overall, researchers found improvements in not only sleep and daytime functioning, but also anxiety and mood in patients [7].

Dosage

Dosage

Dosing with Lunesta should be done with your health professional.

As a guide, starting dose of Lunesta is between 1-2mg at bedtime [2].

Other sources recommend an initial dose of 1mg immediately before bedtime, and, for elderly individuals, Lunesta dose should not exceed 2mg [4].

Lunesta tablets are available in 1mg, 2mg and 3mg doses. Importantly, TOTAL dose of Lunesta should not exceed 3mg, once daily [4].

It is important to note that each Lunesta tablet contains 1mg, 2mg or 3mg eszopiclone (depending on the dose), with other inactive ingredients included in each tablet [4].

Safety

Drug Interactions

Lunesta may interact with other compounds, such as olanzapine which is a drug used to treat schizophrenia, depression and bipolar disorder [5].

Alcohol is another drug that can cause drug-drug interactions with Lunesta [3]. Other interactions may occur with central nervous system (CNS) depressants, and rifampicin, which is an antibiotic [6].

Side Effects  

Side effects of Lunesta can include any one, or more of the following:

  • Dizziness
  • Dry mouth
  • Difficulty maintaining coordination [8].

In most patients, Lunesta leaves a bitter taste in the mouth [3].

Serious side effects, such as hallucinations, memory loss, along with changes in mood, should be reported to your doctor immediately [8].

Lunesta Withdrawal

Withdrawal from Lunesta can occur as a result of mental and physical dependency on Lunesta [9]. Withdrawal symptoms can occur within 12 hours of discontinuing Lunesta, and so it is highly advisable to consult your doctor before quitting [9].

Most people experiencing Lunesta withdrawal will note difficulties in sleep after quitting the drug. Common withdrawal symptoms can include:

  • Anxiety
  • Irritability
  • Tremors
  • Mood swings
  • Panic attacks [9].

Important Information

  • Avoid taking more Lunesta than already prescribed.
  • Do not take Lunesta unless you can maintain a 7-8 hour sleep cycle.
  • Administer Lunesta immediately before going to bed.
  • Contact your GP, or doctor, if insomnia has not improved within 7-10 days [10].
References

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325284/

2. https://www.aafp.org/afp/2005/0615/p2359.html

3. https://www.mdedge.com/psychiatry/article/66112/eszopiclone-targeting-chronic-insomnia

4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021476s030lbl.pdf

5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC518985/

6. https://www.drugbank.ca/drugs/DB01045

7. https://www.ncbi.nlm.nih.gov/pubmed/18458207

8. https://www.webmd.com/drugs/2/drug-92350/lunesta-oral/details

9. https://www.addictioncenter.com/sleeping-pills/lunesta/withdrawal-detox/

10. https://www.lunesta.com/PostedApprovedLabelingText.pdf

Reviews (1)

1 review for Eszopiclone

  1. Rated 5 out of 5

    Glenn Coombs (verified owner) – March 4, 2022

    Best prices and reliable service. Any queries and I’ve always received a fast response and any issues were sorted promptly and fairly. I. have dealt with numerous overseas pharmacy companies but Moda Pharma is at the top of the list for prices and service. I usually order Zopiclone but researched Eszopiclone and found that these tablets last a lot longer than Zopiclone. I noticed that if you are not working the next day and you want something that will last longer than Zopiclone, the Eszopiclone is the pill I would personally recommend. It is also healthier to give yourself a break from Zopiclone as if you abuse this sleeping aid, the strength tends to dissipate gradually. Hope this helps peoples.

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