Pregabalin
£29.75 – £167.45
Shipping: 24h Dispatch with Fast ‘N Insured – UK Shipping | See details
Guarantee: Money Back Guarantee with Free Tracking | See details
Quality: Independent Product Analysis | View certificate
Payments: Buyer Protected via 
| See details
Summary
Pregabalin is an anticonvulsant and anxiolytic medication primarily used to treat neuropathic pain, epilepsy, and generalized anxiety disorder (GAD). It functions by binding to the α2δ subunit of voltage-gated calcium channels in the central nervous system, thereby reducing the release of several neurotransmitters. This modulation leads to decreased neuronal excitability and alleviation of associated symptoms. Pregabalin is well-tolerated in most patients and is available in various dosage forms to accommodate different therapeutic needs.
Detailed
Pregabalin, a structural derivative of the neurotransmitter GABA, does not directly interact with GABA receptors but instead modulates calcium channel function, leading to a reduction in the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. Its primary indications include:
- Neuropathic Pain: Pregabalin is highly effective in managing neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury. The analgesic effect is achieved through the attenuation of hyperexcited neurons.
- Epilepsy: As an adjunctive therapy, Pregabalin is used to control partial seizures in patients aged 12 years and older. Its efficacy in reducing seizure frequency is well-documented in clinical trials.
- Generalized Anxiety Disorder (GAD): Pregabalin is also prescribed for GAD, providing anxiolytic effects through its modulation of overactive neuronal circuits.
Pregabalin is absorbed rapidly with peak plasma concentrations occurring within 1.5 hours after oral administration. The drug is excreted unchanged in the urine, and its pharmacokinetics are linear across the dosing range.
Dosage
The dosage of Pregabalin must be individualized based on the patient’s condition and response to therapy. Common dosages include:
- Neuropathic Pain: Starting dose is typically 75 mg twice daily, which may be increased to 150 mg twice daily within one week, depending on efficacy and tolerability. The maximum dose is 300 mg twice daily.
- Epilepsy: The initial dose is usually 75 mg twice daily, with potential increases up to 600 mg/day, divided into two or three doses.
- Generalized Anxiety Disorder: Starting at 75 mg twice daily, the dose can be increased to 300-450 mg/day based on therapeutic response.
Pregabalin can be taken with or without food, and dose adjustments are necessary for patients with renal impairment.
Additional information
| Strength |
150mg ,300mg ,75mg |
|---|---|
| Quantity of Tablets |
30 ,60 ,90 ,120 ,180 ,300 |